Advancing the therapeutic application of prolonged
Water-Only Fasting

Pioneering a New Medical Paradigm

TrueNorth Health Foundation is leading an initiative to advance the therapeutic application of prolonged water-only fasting through groundbreaking biomedical research and comprehensive clinician training.

We aim to deepen our understanding of human fasting physiology in areas such as immunity and cell regeneration and explore potential therapeutic benefits for various health conditions such as hypertension and obesity.

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Published papers

Publications

TrueNorth Health Foundation conducts clinical research to explore the immediate, sustained, and long-term effects of prolonged water-only fasting and whole-plant refeeding on human health.

Our research is helping to unravel the complexities of fasting physiology and the intervention’s impact on various health conditions.

We invite you to explore our collection of original research articles and case reports on our Publications page.

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Featured Publications

A Six-Week Follow-Up Study on the Sustained Effects of Prolonged Water-Only Fasting and Refeeding on Markers of Cardiometabolic Risk

A Six-Week Follow-Up Study on the Sustained Effects of Prolonged Water-Only Fasting and Refeeding on Markers of Cardiometabolic Risk

Sahmla Gabriel, Mackson Ncube, Evelyn Zeiler, Natasha Thompson, Micaela C. Karlsen, David M. Goldman, Zrinka Glavas, Andrew Beauchesne, Eugene Scharf, Alan C. Goldhamer, Toshia R. Myers
Nutrients 2022

(1) Background: Chronic inflammation and insulin resistance are associated with cardiometabolic diseases, such as cardiovascular disease, type 2 diabetes mellitus, and non-alcoholic fatty liver disease. Therapeutic water-only fasting and whole-plant-food refeeding was previously shown to improve markers of cardiometabolic risk and may be an effective preventative treatment but sustained outcomes are unknown. We conducted a single-arm, open-label, observational study with a six-week post-… Read Article

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Clinical Research

TrueNorth Health Foundation is advancing biomedical knowledge through patient-centered clinical trials that explore the therapeutic potential of prolonged water-only fasting.

We are currently pioneering the first-ever randomized controlled trial to shed light on the efficacy of fasting as a treatment for hypertension, offering new insights into the intervention’s potential role in managing cardiovascular health.

In addition to this landmark trial, TrueNorth Health Foundation is actively engaged in several ongoing small pilot studies exploring various aspects of prolonged water-only fasting. 

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Upcoming Clinical Trials

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Remotely administered fasting in people with multiple cardiometabolic conditions

This pilot study will assess the safety and feasibility of a home-based, remotely supervised fasting and refeeding intervention in people with hypertension, obesity, and other components of metabolic syndrome.

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Fasting in the management of follicular Lymphoma

This preliminary study will begin to observe and quantify the effects of fasting on low-grade follicular lymphoma.

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Does fasting lower Lp(a)?

This pilot study will begin to assess the immediate and long-term effects of prolonged water-only fasting on Lp(a).

Body cell

Fasting in the management of long-COVID

This preliminary study will begin to observe and quantify the effects of fasting on symptoms of long-COVID.

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Clinician Training

TrueNorth Health Foundation is committed to improving patient access to medically supervised prolonged water-only fasting by providing hands-on training for qualified clinicians.

Our program with the TrueNorth Health Center provides comprehensive didactic and practical training for doctors, medical students, and scientists in the medical supervision and research of prolonged water-only fasting.

With personalized clinical mentorship, expert lectures, and access to cutting-edge research, our residents, interns, and fellows acquire the necessary skills and confidence to incorporate fasting into their clinical practice. Join us in shaping the future of healthcare through our opportunities for training in water-only fasting supervision and research.

Medical Residency

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Clinical Internship

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Research Fellowship

Books
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Fasting Literature Database

Explore our Fasting Literature Database with articles published from 1881-1999, to access to a wealth of knowledge on prolonged water-only fasting, spanning a range of topics including physiological effects, clinical applications, and historical perspectives.

Whether you are a seasoned researcher or a curious enthusiast, the literature in our database offers invaluable insights into the rich history and evolving understanding of fasting as a therapeutic intervention.

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Participate in a Clinical Trial

Join us in our TrueNorth Health Foundation mission to advance biomedical knowledge and improve patient care by volunteering to participate in an ongoing or upcoming clinical trial.

Help us unlock the full potential of therapeutic water-only fasting. Learn how you can participate in a study today.

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Support Our Work

Consider a monthly, annual, or estate gift

TrueNorth Health Foundation relies on generous donations to support its biomedical research and public education initiatives. Your contributions also enable the Foundation to provide training for doctors, medical students, and scientists in the medical supervision and research of prolonged water-only fasting.

Help us advance biomedical knowledge and education about how prolonged water-only fasting followed by exclusively whole-plant-food diet affects healthy aging and chronic disease.

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Now Available!

Following on the success of our last book, The Pleasure Trap, our new book Can Fasting Save Your Life? takes a deep dive into the clinical research that supports the many benefits of water-only fasting.

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