Psoriasis is an immune-mediated, inflammatory disease with a chronic relapsing nature that is characterized by increased skin proliferation and systemic manifestations.1 Topical and systemic medications manage inflammation and typically require long-term adherence to avoid relapse. 2 Here we present the case of a man with chronic, severe plaque psoriasis that regressed into remission after a 13-day, medically supervised water-only fast followed by a whole-plant-food diet free of gluten and added salt, oil, and sugar.