Enhancing endocrine therapy activity via fasting cycles: biological rationale and clinical feasibility

Water-only Fasting Literature

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Author(s):

Caffa, I.

Nencioni, A.

Publication:

Mol Cell Oncol

Publication Year:

2021

ISSN:

2372-3556 (Print) 2372-3556 (Linking)

DOI:

10.1080/23723556.2020.1853492

https://www.ncbi.nlm.nih.gov/pubmed/33553607

Abstract

We found that periodic fasting increases the anti-cancer activity of endocrine agents used to treat hormone receptor-positive breast cancer and delays acquired resistance to them by reducing blood leptin, insulin and insulin-like growth factor 1 (IGF1). Our work supports further clinical studies of fasting as an adjuvant to endocrine agents in breast cancer patients.

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