Data are presented on the urinary excretion of sodium and potassium in 40 obese patients subjected to therapeutic starvation. Two patterns of sodium loss were observed: either a uniform low-level loss or a fluctuating loss leading in some cases to marked sodium depletion. In three patients the response was a combination of these two patterns.

The role of glucagon in the metabolic adaptation to prolonged fasting in man has been examined. Plasma immunoreactive glucagon was determined during 6-wk fasts and during infusion of exogenous glucagon using an assay which minimized nonpancreatic immunoreactivity. Plasma glucagon concentrations rose twofold to a peak on the 3rd day of fasting and then declined thereafter to a level maintained… Read More

In women fasted during the second trimester of pregnancy, concentrations of glucose and insulin in the plasma fell to a greater extent and ketone acid concentrations in the blood rose more rapidly than in nonpregnant controls. Nitrogen excretion in the urine, particularly ammonia, was increased in the pregnant group. Continuous glucose utilization by the conceptus may exaggerate and accelerate… Read More