The aim of this study was to compare the kinetics of apolipoprotein (apo)A-I during fed and fasted states in humans, and to determine to what extent the intestine contributes to apoA-I production. A stable isotope study was conducted to determine the kinetics of apoA-I in prebeta1 high-density lipoprotein (HDL) and alpha-HDL. Six healthy male subjects received a constant intravenous infusion… Read More

CONTEXT: Impaired lipid metabolism is linked with obesity-associated insulin resistance, which may be reversed by caloric restriction (CR). OBJECTIVE: In a secondary analysis of a randomized controlled trial, we compared the effects of intermittent fasting (IF) and CR on markers of lipid metabolism in muscle. DESIGN: Seventy-six women (BMI 25-40 kg/m2) were randomized to one of three diets for… Read More

Inconsistencies exist with regard to influence of fasting and energy-restricting diets on markers of glucose and insulin controls. To address these controversial, this study was conducted to determine the impact of fasting diets on fasting blood sugars (FBSs), insulin, homeostatic model assessment insulin resistance (HOMA-IR) and hemoglobin A1c (HbA1c) levels. A comprehensive systematic search… Read More

Cancer is one of the most frequent causes of worldwide death and morbidity and is a major public health problem. Although, there are several widely used treatment methods including chemo-, immune- and radiotherapies, these mostly lack sufficient efficiency and induce toxicities in normal surrounding tissues. Thus, finding new approaches to mitigate side effects and potentially accelerate… Read More

Evidence is accumulating that prolonged fasting (PL) might evoke improvements in metabolic health. Since fasting is accompanied by numerous endogenous processes to equilibrate blood glucose concentration, its feasibility is disputable in people with type 1 diabetes (PWT1D). We aimed to assess the safety and efficacy of PL in c-peptide negative (^< 0.9 ng/mL) PWT1D. Methods: Glucose… Read More

Cases have been reported about refeeding syndrome after bariatric surgery for obesity, in head and neck cancer patients, in patients with anorexia nervosa, hyperemesis gravidarum, in persons on hunger strike, malnourished alcoholic persons and persons doing religious fasting. Refeeding after prolonged fasting can cause severe morbidity and even mortality, if not done properly. Depletion of… Read More

Seborrheic keratosis (SK) is a common skin tumor that is typically benign but can be indistinguishable from malignant tumors. Current treatment methods carry risk of scarring and discoloration and are not always effective. We present the case of a 68-year-old woman with an SK lesion on her right cheek that had been growing for the previous 10 years. During an in-patient water-only fasting and… Read More

INTRODUCTION: Diet may influence various aspects of human health. In fact, it is well known that diet can favour or not the development of various human pathologies, like diabetes, hypertension, and hypercholesterolaemia. Interestingly, diet has an influence in cancer development too (e.g., this relation has been studied for pancreatic,… Read More

Fuchs’ endothelial corneal dystrophy (FECD) is a progressive disorder of the corneal endothelium characterized by endothelial cell functional abnormalities and loss of visual acuity. Chronic oxidative stress plays a key role in disease progression. We present the case of a 69-year-old woman with an 18-year history of FECD that improved after dietary intervention with an exclusively whole-plant… Read More